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PDB Keyword
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PF01904

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    Live PFAM
    Name: Accession: PF01904 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1vpq1vpy1ztv
      

    Resources
    Pfam ID: DUF72 PDB: 1vpq_A
    Solved by: JCSG    
    FFAS:(view)
      Top FFAS hit in PDB: "1vpqA, hypothetical protein TM1631" No significant hits in Pfam.
    Meta-Basic:
      Top significant hit (PDB90): "1vpqA, structural genomics, unknown function ; crystal structure of hypothetical protein (tm1631) from thermotoga maritima at 2.20 a resolution "
    CATH: CATH Domain E-value CATH Node
      1vpqA00 7.80E-75 3.20.20.410
    PUBSERVER: (view)
      Publications(s) found: 996
      Publications(s) meeting filtering criteria: 5
    GeneSilico Metaserver
      PDBBLAST PDB: 1vpy_A SCOP : c.1.32.1 ECC: predicted 2.8.-.-
      FFAS PDB: 1vpq_A SCOP : c.1.32.1
      MGENTHREADER PDB: 1vpq_A SCOP : c.1.32.1
      PRC PDB: 1vpy_A SCOP : c.1.32.1 ECC: predicted 2.8.-.-
      SPARKS PDB: 1vpq_A SCOP : c.1.32.1
      BLASTP PDB: 1vpy_A SCOP : c.1.32.1 ECC: predicted 2.8.-.-
      HHBLITS PDB: 1vpq_A SCOP : c.1.32.1
      COMPASS PDB: 1vpq_A SCOP : c.1.32.1
      CSBLAST PDB: 1vpy_A SCOP : c.1.32.1 ECC: predicted 2.8.-.-
      HHSEARCH PDB: 1vpq_A SCOP : c.1.32.1
    E.coli Annotations
    NCBI: 16129821 PORTECO PORAL: yecE  GeneExpDB: b1868 

    Topsan Members

    Tag pages as 'PF01904' to appear in this list.

    Name Annotation Author(s)
    1vpq
    The TM1631 gene from Thermotoga maritima encodes a protein belonging to a large (~500 homologs, ~400 species) and widely distributed (archaea, eukaryotes, prokaryotes, viruses) family of domains of un... tinab (7 edits)
    pascual (6 edits)
    royk (2 edits)

    Summary

    Pfam family PFAM:PF01904 {Protein of unknown function DUF72 } with 478 members in NR database and additional 168 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1vpq) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1q7za2 classified as TIM beta/alpha-barrel fold. Based on indirect marginal prediction from FFAS then confirmed by structural similarity, one can argue that this family is remotely homologous to other families with this fold.

    Summarizing 1vpq TOPSAN entry, DUF72 members could have a lyase/isomerase enzymatic activity related to DNA repair [Ref] [Ref].

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