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The Open Protein Structure Annotation Network
PDB Keyword
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PF04126

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    3. 3. References
    Live PFAM
    Name: Accession: PF04126 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1zx82ka02nnz
      

    Topsan Members

    Tag pages as 'PF04126' to appear in this list.

    Name Annotation Author(s)
    1zx8
    Gene TM1367 from Thermotoga maritima encodes the NP_229168 protein that belongs to the DUF369 (PF04126) family. Its structure (2ka0) reveals an atypical cyclophilin (peptidylprolyl cis-trans isomerase... pascual (6 edits)
    tinab (1 edits)
    chrisx (1 edits)

    Summary

    Pfam family PFAM:PF04126 {Domain of unknown function (DUF369) } with 108 members in NR database and additional 95 members in the metagenomic datasets is represented in Archaea, and Bacteria. The first structural representative solved (PDB Id: TOPSAN:1zx8) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1v9ta_ classified as Cyclophilin-like fold. (Note: additional/lacking secondary structure elements). Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1v9ta_' this fold. Based on sequence and structure analysis/ original paper one can hypothesize that this family is it will be of interest to investigate whether TM1367 has rotamase activity, binds CsA, or acts as a regulator of calcineurin

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