The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    Live PFAM
    Name: Accession: PF04273 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  2f463gxg3gxh
    GO Terms
    GO:0016787 hydrolase activity function

    Pfam ID: DUF442 PDB: 2f46_A
    Solved by: JCSG    
      Top FFAS hit in PDB: "2f46A, hypothetical protein" Top FFAS hit in Pfam: "PF03162, Tyrosine phosphatase family "
      Top significant hit (PDB90): "2f46A, structural genomics, unknown function ; crystal structure of (7380613) from neisseria meningitidis fam18 at 1.41 a resolution "
      Top significant hit (PFAM25U): "PF03162, Tyrosine phosphatase family"
    CATH: CATH Domain E-value CATH Node
      2imgA00 0.0045
      1yn9C00 0.00017
      1tq1A00 0.0049
    FUNFAM (eval=0 ): Beta-lactamase hydrolase-like protein -like
    PUBSERVER: (view)
      Publications(s) found: 352
      Publications(s) meeting filtering criteria: 7
    GeneSilico Metaserver
      PDBBLAST PDB: 2f46_A SCOP : predicted c.45.1.1
      FFAS PDB: 3gxg_A SCOP : predicted c.45.1.1
      BLASTP PDB: 2f46_A SCOP : predicted c.45.1.1
      HHBLITS PDB: 2f46_A SCOP : predicted c.45.1.1
      COMPASS PDB: 2f46_A SCOP : predicted c.45.1.1
      COMA PDB: 2f46_A SCOP : predicted c.45.1.1
      CSBLAST PDB: 1xi9_A SCOP : c.67.1.1 ECC: predicted 2.6.-.-
      HHSEARCH PDB: 2f46_A SCOP : predicted c.45.1.1

    Topsan Members

    Tag pages as 'PF04273' to appear in this list.

    Name Annotation Author(s)
    The gene NMA1982 from Neisseria meningitidis z2491 encodes the YP_002343251 protein, a  putative tyrosine phosphatase from the DUF442 family (PF04273).   The 2f46 structure belongs to the class of alp... chrisx (3 edits)
    pascual (2 edits)
    kellrott (1 edits)


    Pfam family PFAM:PF04273 {Putative phosphatase (DUF442) } with 398 members in NR database and additional 275 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:2f46) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1ohea2 classified as Phosphotyrosine protein - phosphatases II fold. Profile-profile methods confirm remote homology between this family and superfamily of (Phosphotyrosine protein) phosphatases II; fold of the same name. Based on remote homology confirmed by the structure one can hypothesize that this family is probably protein phosphatase.




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