The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    3. 3. References

    Live PFAM
    Name: Accession: PF04359 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1rwu2h9z2joq

    Pfam ID: DUF493 PDB: 1rwu_A
    Solved by: NESG    
      Top FFAS hit in PDB: "1rwuA, Hypothetical UPF0250 protein ybeD" Top FFAS hit in Pfam: "PF13291, ACT domain "
      Top significant hit (PDB90): "1rwuA, structural genomics, unknown function ; solution structure of conserved protein ybed from e. coli "
      Top significant hit (PFAM25U): "PF13291, ACT domain"
    CATH: CATH Domain E-value CATH Node
      1rwuA00 1.80E-26
      2ko1B00 0.0015
    PUBSERVER: (view)
      Publications(s) found: 684
      Publications(s) meeting filtering criteria: 5
    GeneSilico Metaserver
      FFAS PDB: 1rwu_A SCOP : d.58.54.1
      PHYRE PDB: 1rwu_A SCOP : d.58.54.1
      MGENTHREADER PDB: 2joq_A SCOP : predicted d.58.18.6
      PRC PDB: 1rwu_A SCOP : d.58.54.1
      SPARKS PDB: 1rwu_A SCOP : d.58.54.1
      HHBLITS PDB: 1rwu_A SCOP : d.58.54.1
      COMPASS PDB: 1rwu_A SCOP : d.58.54.1
      HHSEARCH PDB: 1rwu_A SCOP : d.58.54.1
    E.coli Annotations
    NCBI: 16128614 PORTECO PORAL: ybeD  GeneExpDB: b0631 

    Topsan Members

    Tag pages as 'PF04359' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF04359 {Protein of unknown function (DUF493) } with 339 members in NR database and additional 127 members in the metagenomic datasets is represented in Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1rwu) was shown to be similar to SCOP (v. 1.73) domain SCOP:d1q5ya_ to ACT small-molecule binding allosteric regulatory domains (Pfam ACT clan)  [Ref]. Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known proteins from this clan. Based on sequence and structure analysis/ original paper one can hypothesize that this family is plays a role in the allosteric regulation of lipoic acid biosynthesis, being also involved in stress response.




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