The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

    Live PFAM
    Name: Accession: PF04379 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1tza1xq41xvs2f1e

    Pfam ID: DUF525 PDB: 1tza_A
    Solved by: NESG    
      Top FFAS hit in PDB: "1xvsA, Protein apaG" Top FFAS hit in Pfam: "PF14263, Domain of unknown function (DUF4354) "
      Top significant hit (PDB90): "1xq4A, structural genomics, unknown function ; crystal structure of the putative apaa protein from bordetella pertussis, northeast structural genomics target ber40 "
    CATH: CATH Domain E-value CATH Node
      1xvsA00 1.30E-35
    FUNFAM (eval=0 ): Temporarily assigned gene name protein 307 -like
    PUBSERVER: (view)
      Publications(s) found: 824
      Publications(s) meeting filtering criteria: 21
    GeneSilico Metaserver
      PDBBLAST PDB: 1xq4_A SCOP : b.1.23.1
      FFAS PDB: 1tza_A SCOP : b.1.23.1
      MGENTHREADER PDB: 2f1e_A SCOP : predicted b.1.23.1
      PRC PDB: 1tza_A SCOP : b.1.23.1
      SPARKS PDB: 1tza_A SCOP : b.1.23.1
      BLASTP PDB: 1xvs_A SCOP : b.1.23.1
      HHBLITS PDB: 2f1e_A SCOP : predicted b.1.23.1
      COMPASS PDB: 1tza_A SCOP : b.1.23.1
      CSBLAST PDB: 1xq4_A SCOP : b.1.23.1
      HHSEARCH PDB: 1xq4_A SCOP : b.1.23.1
    E.coli Annotations
    NCBI: 16128044 PORTECO PORAL: apaG  GeneExpDB: b0050 

    Topsan Members

    Tag pages as 'PF04379' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF04379 {Protein of unknown function (DUF525) } with 837 members in NR database and additional 530 members in the metagenomic datasets is represented in Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1tza) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1vjja3 classified as Immunoglobulin-like beta-sandwich fold. Based on indirect marginal prediction from FFAS then confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1vjja3' this fold.

    On the one side of beta-sheet highly specific conserved residues forming unusual wide bounce, likely the recognition site for small ligand. Docking can be applied to check the potential partner.




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