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The Open Protein Structure Annotation Network
PDB Keyword
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PF06849

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    Live PFAM
    Name: Accession: PF06849 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  2pbz2r7k2r7l2r7m2r7n
    GO Terms
    GO:0016879 ligase activity, forming carbon-nitrogen bonds function
    GO:0000287 magnesium ion binding function
    GO:0006188 IMP biosynthetic process process
    GO:0005524 ATP binding function
      

    Resources
    Pfam ID: DUF1246 PDB: 2pbz_A
    Solved by: NYSGXRC    
    FFAS:(view)
      Top FFAS hit in PDB: "2r7kA, 5-formaminoimidazole-4-carboxamide-1-(beta)-D" No significant hits in Pfam.
    Meta-Basic:
      Top significant hit (PDB90): "2r7kA, ligase ; crystal structure of faicar synthetase (purp) from m. jannaschii complexed with amppcp and aicar "
    CATH: CATH Domain E-value CATH Node
      2r85A01 1.90E-26 3.40.50.20
    FUNFAM (eval=0 ): 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase -like
    PUBSERVER: (view)
      Publications(s) found: 87
      Publications(s) meeting filtering criteria: 3
    GeneSilico Metaserver
      PDBBLAST PDB: 2r7k_A SCOP : predicted d.142.1 ECC: 6.3.4.-
      FFAS PDB: 2pbz_A SCOP : c.30.1.8 ECC: 6.3.4.-
      BLASTP PDB: 2r7k_A SCOP : predicted d.142.1 ECC: 6.3.4.-
      HHBLITS PDB: 2pbz_A SCOP : c.30.1.8 ECC: 6.3.4.-
      COMPASS PDB: 2r7k_A SCOP : predicted d.142.1 ECC: 6.3.4.-
      CSBLAST PDB: 2r7k_A SCOP : predicted d.142.1 ECC: 6.3.4.-
      HHSEARCH PDB: 2pbz_A SCOP : c.30.1.8 ECC: 6.3.4.-

    Topsan Members

    Tag pages as 'PF06849' to appear in this list.

    Name Annotation Author(s)
    2pbz

    Summary

    Pfam family PFAM:PF06849 {Protein of unknown function (DUF1246)} with 175 members in NR database and additional 121 members in the metagenomic datasets is represented in Archaea, and Bacteria. The first structural representative solved (PDB Id: TOPSAN:2pbz) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1b6ra3 classified as preATP-grasp domain fold. Based on Ligand one can argue that this family is remotely homologous to previously known structures from 'd1b6ra3' this fold. Based on fold and evidence of homology, ligand one can hypothesize that this family is ligase; IMP biosynthesis protein PURP; protein is trimer with ATP in each monomer.

    Reviews

    References

     

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