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    1. 1. Topsan Members
    2. 2. Summary

    Live PFAM
    Name: Accession: PF08964 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1ag41hdf1yhp2b1o3ent

    Pfam ID: DUF1881 PDB: 1ag4_A
    Solved by: non-psi    
      Top FFAS hit in PDB: "1yhpA, Calcium-dependent cell adhesion molecule-1" Top FFAS hit in Pfam: "PF00030, Beta/Gamma crystallin "
      Top significant hit (PDB90): "1yhpA, cell adhesion ; solution structure of ca2+free ddcad-1 "
      Top significant hit (PFAM25U): "PF00030, Beta/Gamma crystallin"
    CATH: CATH Domain E-value CATH Node
      2k1wA00 0.0014
      3i9hE00 1.60E-05
    FUNFAM (eval=0 ): Calcium-dependent cell adhesion molecule 1 -like
    PUBSERVER: (view)
      Publications(s) found: 18
      Publications(s) meeting filtering criteria: 6

    Topsan Members

    Tag pages as 'PF08964' to appear in this list.

    No TOPSAN member(s) found.


    Representative of this family in Dictyostelium discoideum was characterized as a Ca2+-binding protein implicated in the cell-cell adhesion.

    DdCAD-1 contains two beta-sandwich domains: N-terminal beta-gamma-crystallin and C-terminal immunoglobulin domain. The former has a major role in homophilic binding and belongs to gamma-Crystallin-like superfamily (CL0333 Pfam clan), while the latter tethers the protein to the cell membrane and should probably belong to Ig clan (Cl0011).

    This family can be renamed as DdCAD.


    Wong EF, Brar SK, Sesaki H, Yang C, Siu CH. Molecular cloning and
    characterization of DdCAD-1, a Ca2+-dependent cell-cell adhesion molecule, in
    Dictyostelium discoideum. J Biol Chem. 1996 Jul 5;271(27):16399-408. PubMed PMID:

    PMID: 8663243




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