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PDB Keyword
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PF09298

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

    Live PFAM
    Name: Accession: PF09298 (PFAM live)
    # sequence matches: # architectures:
    # taxonomy ids: PDB:  1hyo1qcn1qco1qqj2hzy
    GO Terms
    GO:0009072 aromatic amino acid family metabolic process process
    GO:0004334 fumarylacetoacetase activity function
      

    Resources
    Pfam ID: DUF1969 PDB: 1hyo_A
    Solved by: non-psi    
    FFAS:(view)
      Top FFAS hit in PDB: "1qcoA, FUMARYLACETOACETATE HYDROLASE" No significant hits in Pfam.
    Meta-Basic:
      Top significant hit (PDB90): "1qcoA, hydrolase ; crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate "
    CATH: CATH Domain E-value CATH Node
      1hyoA01 5.00E-30 2.30.30.230
    FUNFAM (eval=0 ): Putative uncharacterized protein -like
    PUBSERVER: (view)
      Publications(s) found: 390
      Publications(s) meeting filtering criteria: 46
    GeneSilico Metaserver
      PDBBLAST PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      MGENTHREADER PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      PRC PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      SPARKS PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      BLASTP PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      HHBLITS PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      COMPASS PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      CSBLAST PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2
      HHSEARCH PDB: 1hyo_A SCOP : predicted d.177.1 ECC: 3.7.1.2

    Topsan Members

    Tag pages as 'PF09298' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    This is an N-terminal domain of fumarylacetoacetate hydrolase, whose exact functional role is unknown. It is structuraly similar to N-terminal domains in 3lzk, aromatic amino acid degradation protein solved by MCSG. Also many other hydrolases, annotates usually as fumarylacetoacetate or 2-keto-4-pentenoate hydratases have this domain. This similarity is not recognized by any of the distant homology recognition programs.

    3lzk_Ndomain.png

     The occurrence of HT1-associated mutations within this domain and in the N-C interdomain interface suggests its minimal structural requirement, although a regulatory function is conceivable given the contacts to the C-terminal beta-roll.

    This domain will be renamed in the Pfam to "FAA_hydrolase_N" or "FAAH_N".

    Reviews

    References

     

    No references found.

    Tag page

    Files (1)

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     3lzk_Ndomain.png
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    153.43 kB17:25, 24 Jan 2012adamActions
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