.
The Open Protein Structure Annotation Network
PDB Keyword
.

Q15751

    Q15751 Annotations
    Resources: GeneCardsLocal Structure PredictionUNIPROTPFAM, Interpro
     


    Q15751 148-267 Putative Domain Summary

    According to profile-profile comparison methods, this domains shares certain similarity with a region within the N-terminal ubiquitin-like domain (PDB ID: 1WX7_A).

    Q15751 148-267 Domain Information
    Sequence Length: 120 Sequence Local Structure Prediction # Uniprot Refs: 7
    N-terminal boundary: low complexity region C-terminal boundary: disordered region
    Is region cluster seed?: No   Cluster Size: 3  
    HMMER:
      # sequence matches: 60 # architectures: 24 # taxonomy ids: 33
    FFAS:
      No significant hits in PDB.
      No significant hits in Pfam.
    GRDB


    Q15751 986-1314 Putative Domain Summary

    The HECT domain (Homologous to the E6-AP Carboxyl Terminus) is an approximately 40 kDa (350 amino acid) catalytic domain found at the C-terminus of HECT-class E3 ubiquitin protein ligases. This domain binds specific E2 enzymes, accepts ubiquitin from E2 to form an ubiquitin-thioester intermediate with the HECT active cysteine, and then transfers ubiquitin to either the ε-amino groups of lysine side chains of the substrate or to the growing end of multiubiquitin chains. The formation of a thioester intermediate with ubiquitin is unique to HECT E3 ligases and is not seen with other types of E3 ligase.

    Q15751 986-1314 Domain Information
    Sequence Length: 329 Sequence Local Structure Prediction # Uniprot Refs: 7
    N-terminal boundary: disordered region C-terminal boundary: disordered region
    Is region cluster seed?: Yes   Cluster Size: 2  
    HMMER:
      # sequence matches: 23 # architectures: 14 # taxonomy ids: 14
    FFAS:
      No significant hits in PDB.
      No significant hits in Pfam.
    GRDB


    Q15751 1723-1860 Putative Domain Summary

    Your annotation here.

    Q15751 1723-1860 Domain Information
    Sequence Length: 138 Sequence Local Structure Prediction # Uniprot Refs: 7
    N-terminal boundary: disordered region C-terminal boundary: disordered region
    Is region cluster seed?: Yes   Cluster Size: 1  
    HMMER:
      # sequence matches: 14 # architectures: 8 # taxonomy ids: 10
    FFAS:
      No significant hits in PDB.
      No significant hits in Pfam.
    GRDB


    Q15751 2292-2403 Putative Domain Summary

    Your annotation here.

    Q15751 2292-2403 Domain Information
    Sequence Length: 112 Sequence Local Structure Prediction # Uniprot Refs: 7
    N-terminal boundary: disordered region C-terminal boundary: disordered region
    Is region cluster seed?: No   Cluster Size: 2  
    HMMER:
      # sequence matches: 24 # architectures: 12 # taxonomy ids: 15
    FFAS:
      No significant hits in PDB.
      No significant hits in Pfam.
    GRDB


    Q15751 3832-3997 Putative Domain Summary

    Your annotation here.

    Q15751 3832-3997 Domain Information
    Sequence Length: 166 Sequence Local Structure Prediction # Uniprot Refs: 7
    N-terminal boundary: psi-blast hit in PDB C-terminal boundary: psi-blast hit in PDB
    Is region cluster seed?: Yes   Cluster Size: 1  
    HMMER:
      # sequence matches: 59 # architectures: 31 # taxonomy ids: 36
    FFAS:
      No significant hits in PDB.
      No significant hits in Pfam.
    GRDB


    Topsan Members

    Tag pages as 'Q15751' to appear in this list.

    No TOPSAN member(s) found.

    Reviews

    References

     

    No references found.

    Files (0)

     
    You must login to post a comment.
    All content on this site is licensed under a Creative Commons Attribution 3.0 License
    Powered by MindTouch