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    Q86WI3 Annotations
    Resources: GeneCardsLocal Structure PredictionUNIPROTPFAM, Interpro

    Q86WI3 414-610 Putative Domain Summary

    This (putative!) domain has a long history. This is a linker between the NACHT and LRR domains in NLR proteins (NOD-like receptors, intracelluar innate immunity receptors). We tried to publish it in TIBS new domain section, but got rejected mostly on the argument that it is an extension of the NACHT domain. Tshopp calls it a NAD (NACHT associated domain) in the Nature review of NALPs. It probably consists of a series of short helical domains composed of three stacked helices (by analogy to a domain between NBARC AAA domain and WD repeats in APAF1 and other post-AAA regions in other ATPases). Stefan Riedl from Burnham is trying to crystallize NACHT + NAD domain for a while now (others do it). In EM pictures of inflammasomes it appears to be structured.


    Q86WI3 414-610 Domain Information
    Sequence Length: 197 Sequence Local Structure Prediction # Uniprot Refs: 5
    N-terminal boundary: psi-blast hit in PDB C-terminal boundary: psi-blast hit in PDB
    Is region cluster seed?: Yes   Cluster Size: 2  
      # sequence matches: 122 # architectures: 18 # taxonomy ids: 15
      No significant hits in PDB.
      No significant hits in Pfam.

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