.
The Open Protein Structure Annotation Network
PDB Keyword
.

Sestrin

    Table of contents
    1. 1. Summary

    Tag pages as 'Sestrin' to appear in this list.

    Name Annotation Author(s)
    3bey
    1vke
    TM1620 belongs (by sequence similarity) to carboxymuconolactone decarboxylase (CMD) family (Pfam02627), CMD, EC:4.1.1.44 is involved in protocatechuate catabolism. Some members of this family, such as...
    3c1l
    Gene mlr4105 from Mesorhizobium loti translates into the putative antioxidant defense protein (NP_105057.1) that belongs to the CMD group (PF02627). ZP_01012034, annotated as alkylhydroperoxidase fam... pascual (4 edits)
    chrisx (1 edits)
    2qeu
     The gene Bxe_C0569 gene (PF02627) in Burkholderia xenovorans LB400 encodes for a putative carboxymuconolactone decarboxylase (CMD). The protein structure shows very high structure similarity to the P... chrisx (1 edits)
    2ouw
    YP_425393.1 (UniProt:Q2RXN9_RHORT) belongs (by sequence similarity) to carboxymuconolactone decarboxylase (CMD) family (Pfam02627), CMD, EC:4.1.1.44 is involved in protocatechuate catabolism. Some mem... pascual (4 edits)
    2pfx
    Gene TM1040_2465 from Silicibacter sp. codifies for the YP_614459 sequence that belongs to the CarboxyMuconolactone Decarboxylase, CMD, group (PF02627). It shows 90% identity with the alkylhydroperoxi... pascual (3 edits)
    2prr
    Reut_A2532 gene translates into the YP_296737 sequence that belongs to the putative alkylhydroperoxidase AhpD core protein, characterized by the conserved motif C86--C89---H93 of the CarboxyMuconolact... pascual (4 edits)
    2oyo
    The Dgeo_1446 gene encodes the YP_604910.1 amino acid sequence which folds into a single domain 195 residues long protein showing the signature of the Carboxy-Mucono-lactone Decarboxylase (CMD) group ... pascual (10 edits)

    Summary

    Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress, as well as mediate p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. Sestrin also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Distant homology to bacterial AhpD proteins, several of which were solved by JCSG, provides a structural template for sestrin. It also illustrates the conservation of DNA defence mechanisms between eukaryotes and bacteria.

     

     

    Also 3lvy, 2gmy, 1p8c (identical to our 1vke) (MCSG), 2od4 (SCG?), 3bey (NESG), 2cwq (RIKEN), 3bjx, 1gu9,  (non-PSI)

    Reviews

    References

     

    No references found.

    Tag page

    Files (0)

     
    You must login to post a comment.
    All content on this site is licensed under a Creative Commons Attribution 3.0 License
    Powered by MindTouch