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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title NMR Structure of the Conserved Hypothetical Protein Tm0487 from Thermotoga Maritima: Implications for 216 Homologous Duf59 Proteins. Protein Sci. 14 2880 2005
    Site JCSG
    PDB Id 1wcj Target Id 282360
    Related PDB Ids 1uwd 
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1208,TM0487, 84914 Molecular Weight 11637.98 Da.
    Residues 104 Isoelectric Point 4.39
    Sequence mpmskkvtkedvlnalknvidfelgldvvslglvydiqiddqnnvkvlmtmttpmcplagmilsdaeea ikkiegvnnveveltfdppwtpermspelrekfgv
      BLAST   FFAS

    Structure Determination
    Method NMR Chains 1

    Ligand Information


    Google Scholar output for 1wcj
    1. Physics-based protein-structure prediction using a hierarchical protocol based on the UNRES force field: Assessment in two blind tests
    S O_dziej, C Czaplewski, A Liwo - Proceedings of the , 2005 - National Acad Sciences
    2. Domain definition and target classification for CASP6
    M Tress, CH Tai, G Wang, I Ezkurdia - PROTEINS: , 2005 - Wiley Online Library
    3. Protein structure prediction: combining de novo modeling with sparse experimental data
    D Latek, D Ekonomiuk, A Kolinski - Journal of computational , 2007 - Wiley Online Library
    4. Protein structure prediction: The next generation
    MC Prentiss, C Hardin, MP Eastwood - Journal of Chemical , 2006 - ACS Publications
    5. NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: Implications for 216 homologous DUF59 proteins
    MS Almeida, T Herrmann, W Peti, IA Wilson - Protein , 2005 - Wiley Online Library
    6. Soft energy function and generic evolutionary method for discriminating native from nonnative protein conformations
    Y Chiu, J Hwang, J Yang - Journal of computational chemistry, 2008 - Wiley Online Library
    7. Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a
    C Mas, KE Chen, IM Brereton, JL Martin - Biomolecular NMR , 2012 - Springer

    Protein Summary

    The TM0487 gene from Thermotoga maritima encodes the NP_228297 protein from the DUF59 family (PF01883). The family also includes PhaH from Pseudomonas putida. PhaH forms a complex with PhaF, PhaG and PhaI, which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid [Ref]. The members of this family may all be components of ring hydroxylating complexes. TM0487 homolog (67% seq. id.) from Thermosipho africanus (YP_002335513) is annotated as metal-sulfur cluster biosynthetic enzyme. TM0487 genomic neighbor, TM0488, is annotated as HemK protein.

    The NMR structure of NP_228297 protein has been deposited in the PDB database (1UWD). SCOP classifies 1uwd in the alpha+beta class, alpha-lytic protease prodomain-like fold, Fe-S cluster assembly domain-like superfamily, PaaD-like family. DALI top hits are with the TTHB138 protein 3cq2 (Z=12), and the rhamnose reductase related protein 2cu6 (Z=11).

    Ligand Summary





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