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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein. Plos One 6 e17624-e17624 2011
    Site JCSG
    PDB Id 3hn7 Target Id 391146
    Molecular Characteristics
    Source Psychrobacter arcticus 273-4
    Alias Ids TPS25718,YP_263340.1, 3.40.1190.10, 291233 Molecular Weight 54885.23 Da.
    Residues 505 Isoelectric Point 5.30
    Sequence mhihilgicgtfmgslallaralghtvtgsdaniyppmstqleqagvtieegyliahlqpapdlvvvgn amkrgmdvieymldtglrytsgpqflseqvlqsrhviavagthgktttttmlawilhyagidagfligg vplvnttdtnlqqvfahssylgtekddsdnsvntgyfvieadeydsaffdkrskfvhyrprtailnnle fdhadifadldaiqtqfhhmvrmipstgkiimpaatisledtlakgvwtpiwrtsvidstissvrreds plensqaenssdwqaelisadgsqftvsfndnkeatalvnwsmsglhnvnnalvaiaaaynigvsvkta caalsafagikrrmeligdvndilvfddfahhptaitttldgakkkladrrlwaiieprsntmkmgihq dslaqsatladhtlwyeptglewglkevidnatianpsigsqqvlssvddiikhicthakagdaivims nggfegihqrlltalgnivail
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.65 Rfree 0.187
    Matthews' coefficent 2.13 Rfactor 0.154
    Waters 599 Solvent Content 42.36

    Ligand Information


    Google Scholar output for 3hn7
    1. Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein
    D Das, M Herv, J Feuerhelm, CL Farr, HJ Chiu - PloS one, 2011 - dx.plos.org

    Protein Summary

    The Psyc_0032 gene from Psychrobacter arcticum 273-4 codes for the YP_263340 multidomain protein that is annotated as a putative UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase belonging to Pfams PF01225 (Mur_ligase), PF08245 (Mur_ligase middle domain) and PF02875 (Mur_ligase glutamate ligase domain).

    Pre-SCOP classifies 3hn7 as follows: the 1-90 fragment in the MurCD N-terminal domain (super)family; the 98-352 fragment inside the MurD-like peptide ligases, catalytic domain superfamily; and the 354-498 C-terminal fragment in the MurD-like peptide ligases, peptide binding domain superfamily. DALI top hits are with other acetylmurate-Ala ligases like PDB:3eag (Z=38), PDB:1p3d (Z=33), PDB:2f00 (Z=32) and PDB:1j6u (Z=30).

    3hn7 appears as a monomer in the crystal structure (colored from N-term, blue to C-term, red).Fig1.png

    Ligand Summary




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