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2fdj

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 439 879-884 2006
    Site NESGC
    PDB Id 2fdj Target Id ER126
    Related PDB Ids 2fdk 2fdi 2fdh 2fdg 2fd8 2fdf 
    Molecular Characteristics
    Source Escherichia coli
    Alias Ids TPS8825,2.60.120.590, BIG_205 Molecular Weight 24074.24 Da.
    Residues 216 Isoelectric Point 7.73
    Sequence mldlfadaepwqeplaagavilrrfafnaaeqlirdindvasqspfrqmvtpggytmsvamtncghlgw tthrqgylyspidpqtnkpwpampqsfhnlcqraataagypdfqpdaclinryapgaklslhqdkdepd lrapivsvslglpaifqfgglkrndplkrlllehgdvvvwggesrlfyhgiqplkagfhpltidcrynl tfrqagkke
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.10 Rfree 0.229
    Matthews' coefficent 2.11 Rfactor 0.178
    Waters 259 Solvent Content 41.78

    Ligand Information
    Ligands SIN (SUCCINIC) x 1
    Metals FE2 (FE) x 1

    Jmol

     
    Google Scholar output for 2fdj
    1. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
    KS Hewitson, BMR Linard, MA McDonough - Journal of Biological , 2007 - ASBMB
     
    2. Structural and mechanistic studies on the inhibition of the HIF hydroxylases by tricarboxylic acid cycle intermediates
    KS Hewitson, BMR Linard, MA McDonough - Journal of Biological , 2006 - ASBMB
     
    3. Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate Dependent Nucleic Acid Demethylase
    ECY Woon, M Demetriades, EAL Bagg - Journal of Medicinal , 2012 - ACS Publications
     
    4. Homology modeling and function prediction of hABH1, involving in repair of alkylation damaged DNA
    S Das, AS Vidyarthi - Interdisciplinary Sciences: Computational Life , 2011 - Springer
     

    Protein Summary


    Ligand Summary

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