The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structures of two putative phosphoheptose isomerases. Proteins 63 1092-1096 2006
    Site NYSGXRC
    PDB Id 1tk9 Target Id NYSGXRC-T1512
    Molecular Characteristics
    Source Campylobacter jejuni
    Alias Ids TPS8183,15792473 Molecular Weight 21437.53 Da.
    Residues 198 Isoelectric Point 6.40
    Sequence mslinlvekewqehqkivqaseilkgqiakvgellceclkkggkilicgnggsaadaqhfaaelsgryk kerkalagialttdtsalsaigndygfefvfsrqvealgnekdvligistsgkspnvlealkkakelnm lclglsgkgggmmnklcdhnlvvpsddtariqemhiliihtlcqiidesfeggshhhhhh
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 4
    Resolution (Å) 2.10 Rfree 0.211
    Matthews' coefficent 2.42 Rfactor 0.182
    Waters 699 Solvent Content 48.80

    Ligand Information


    Google Scholar output for 1tk9
    1. Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants
    PL Taylor, KM Blakely, GP de Leon, JR Walker - Journal of Biological , 2008 - ASBMB
    2. Structural similarity between the DnaA_binding proteins HobA (HP1230) from Helicobacter pylori and DiaA from Escherichia coli
    G Natrajan, DR Hall, AC Thompson - Molecular , 2007 - Wiley Online Library
    3. N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism
    T Jaeger, C Mayer - Cellular and Molecular Life Sciences, 2008 - Springer
    4. The Structure of Sedoheptulose-7-Phosphate Isomerase from Burkholderia pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site
    NJ Harmer - Journal of molecular biology, 2010 - Elsevier
    5. Predicting conserved essential genes in bacteria: in silico identification of putative drug targets
    M Duffield, I Cooper, E McAlister, M Bayliss, D Ford - Mol. BioSyst., 2010 - xlink.rsc.org
    6. Crystal structures of two putative phosphoheptose isomerases
    J Seetharaman, KR Rajashankar - Proteins: Structure, , 2006 - Wiley Online Library
    7. Crystal structure of YfeU protein from Haemophilus influenzae: a predicted etherase involved in peptidoglycan recycling
    Y Kim, P Quartey, R Ng, TI Zarembinski - Journal of structural and , 2009 - Springer
    8. Crystallographic and NMR Studies of Aquifex Aeolicus Phosphoheptose Isomerase: Structural Insights into the Mechanism of Aldose-Ketose Isomerization.
    V Thai, G Petsko, D Kern - The role of structure and dynamics in , 2007 - books.google.com
    9. In silico quest for putative drug targets in Helicobacter pylori HPAG1: molecular modeling of candidate enzymes from lipopolysaccharide biosynthesis pathway
    M Sarkar, L Maganti, N Ghoshal, C Dutta - Journal of Molecular Modeling, 2011 - Springer

    Protein Summary

    Ligand Summary




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